0036 UPPER AIRWAY OBSTRUCTION AND OBSTRUCTION REMOVAL ARE ASSOCIATED WITH ABNORMAL ENERGY METABOLISM AND CHANGES IN GROWTH HORMONE AXIS IN RATS

Role of growth hormone-releasing hormone in sleep and growth impairments induced by upper airway obstruction in rats.

Upper airway obstruction (UAO) can lead to abnormal growth hormone (GH) homeostasis and growth retardation but the mechanisms are unclear. We explored the effect of UAO on hypothalamic GH-releasing hormone (GHRH), which has a role in both sleep and GH regulation. The tracheae of 22-day-old rats were narrowed; UAO and sham-operated animals were sacrificed 16 days post-surgery. To stimulate slow-...

Upper airway obstruction in children

In this review, the characters of children who are admi t ted to PICU wi th severe upper a i rway obstruction will be discussed further. Difficulties of in tubat ion, ind icat ions and compl icat ions o f t racheo tomy w i l l be d i scussed a f te rwards . Angioedema, bacterial tracheitis, acute epiglottitis and croup will be discussed with details separately. Laryngomalacia will also be discu...

Upper airway obstruction in children.

Poiseuille’s law is central to the understanding and management of all airway obstructions in children, with the clinical impact of even a small reduction in radius being compounded by the inverse relationship of the resistance to the radius to the power 4. Indeed deterioration from a ‘mild’ obstruction to life threatening airway compromise may be heralded by slight decrease in airway diameter ...

Upper Airway Obstruction*

Chronic upper airway obstruction is frequently unrecognized or misdiagnosed as other conditions such as asthma or chronic airflow obstruction (CAO). Clinical features such as stridor may lead to diagnosis or it may initially be suspected from the results of pulmonary function tests (PFTs) ordered for another reason. We will review the physiology and the pulmonary function tests which are necess...

Stridor and upper airway obstruction in children.